About UMass Amherst
UMass Amherst, the Commonwealth's flagship campus, is a nationally ranked public research university offering a full range of undergraduate, graduate and professional degrees. The University sits on nearly 1,450-acres in the scenic Pioneer Valley of Western Massachusetts, and offers a rich cultural environment in a bucolic setting close to major urban centers. In addition, the University is part of the Five Colleges (including Amherst College, Hampshire College, Mount Holyoke College, and Smith College), which adds to the intellectual energy of the region.
The Skouta group (http://people.chem.umass.edu/skouta/) is seeking a highly motivated synthetic medicinal chemistry post-doc to join the new laboratory. The Skouta Group research covers medicinal chemistry, protein chemistry, computer modeling, biological assays and in vitro studies. The major therapeutic focuses are cancer, neurodegeneration and infection diseases. The successful candidate will be involved in the design and synthesis of small molecule drug candidates with well-defined mode of action for the development of better therapeutic treatments.
Examples of duties:
- Develop an elegant synthetic pathway of the desired scaffold to create a set of analogs efficiently.
- Creation of analogues with high purity for biology testing.
- Structure activity relationship study an invitro testing of biologically active compounds with better drug-like properties
- ADME/PK/toxicity testing
- Development of in vitro assays such as knock out genes of interest (CRISPR/Cas9) to evaluate the biological properties of the compounds.
- Work collaboratively and effectively to promote teamwork, diversity, equality and inclusiveness.
- Work in partnership with colleagues within the CNS community and across the campus to support the Dean’s strategic priorities.
- Perform other duties as assigned in support of the mission and goals of the College of Natural Sciences.
Minimum Qualifications (Knowledge, Skills, Abilities, Education, Experience, Certifications, Licensure)
- Must have a Ph.D. in chemistry, medicinal chemistry or a related field.
- Previous work with drug design and creation of novel molecules.
- Interest in evaluating small molecules against a panel of cell lines.
- Experience with mentoring students and collaborative work with other groups.
- Excellent written and oral communication skills.
- Needs be to proficient in designing synthetic routes and solving challenging problems in multi-step synthesis.
- Needs to have medicinal chemistry knowledge including but not limited to ligand-receptor interactions and structure-based drug design, SAR exploration, parallel and library synthesis, computer modeling, biological tests including cell line assay and in vivo studies, etc.
Physical Demands/Working Conditions
- Manual dexterity and laboratory skills consistent with the research being performed.
- Direct supervision by the P.I. (Rachid Skouta).
- May help mentor students.
- Will establish some independence in research design and execution, and to publish his/her work as appropriate in collaboration with the principal investigator.
- Salary will commensurate with qualifications and experience and is consistent with bargaining unit contract.
Special Instructions to Applicants
To apply, please submit a cover letter, resume, a summary of research accomplishments and contact information for three professional references. Search may remain open until a suitable candidate pool has been identified.
As part of a commitment to their own multicultural community, CNS seeks an individual with a demonstrated commitment to diversity and one who will understand and embrace university initiatives and aspirations. http://www.cns.umass.edu/diversity-equity-inclusion.
UMass Amherst is committed to a policy of equal opportunity without regard to race, color, religion, gender, gender identity or expression, age, sexual orientation, national origin, ancestry, disability, military status, or genetic information in employment, admission to and participation in academic programs, activities, and services, and the selection of vendors who provide services or products to the University. To fulfill that policy, UMass Amherst is further committed to a program of affirmative action to eliminate or mitigate artificial barriers and to increase opportunities for the recruitment and advancement of qualified minorities, women, persons with disabilities, and covered veterans. It is the policy of the UMass Amherst to comply with the applicable federal and state statutes, rules, and regulations concerning equal opportunity and affirmative action.